Brian Jordan Alvarez

Will (Eric McCormack), Grace (Debra Messing) and Jack (Sean Hayes) are upset when they discover they’ve been too preoccupied with the changes in their own lives: Will teaching law at Columbia, Grace running for president of the New York Interior Designers Society and Jack’s new relationship with Estefan (guest star Brian Jordan Alvarez) to even notice Karen (Megan Mullally) has not been seen in days -- ever since her husband found out about her affair with Malcolm (guest star Alec Baldwin).

Grace's (Debra Messing) accidental run in with Noah (guest star David Schwimmer), a curmudgeonly man she follows on Twitter, hints at a possible new love interest. Jack (Sean Hayes) wants to look younger before meeting Estefan's (guest star Brian Jordan Alvarez) family on Skype but makes a terrible first impression after overdoing the numbing cream before his facial procedure. Meanwhile, Will (Eric McCormack) helps Karen (Megan Mullally) protect the intellectual property rights of her most prized possession.

Grace's (Debra Messing) father and Will's (Eric McCormack) mother end up making a surprising and upsetting connection. Jack (Sean Hayes) rebounds from his breakup with a new love. Karen (Megan Mullally) must decide between her husband and her lover.

Grace returns from her European travels a new woman but soon receives life-changing news.

Will (Eric McCormack) and Grace's (Debra Messing) plan to win over Will's new Columbia department head goes awry when he drops dead in their apartment - and they use his phone to text his full recommendation of Will. Karen (Megan Mullally) and Estefan's (guest star Brian Jordan Alvarez) dislike for each other puts Jack (Sean Hayes) in full damage control mode when he must keep them separate at his birthday dinner.