AZ Alkmaar open their run in the Europa League against Swedish side IF Elfsborg, who currently sit third in the Allsvenskan.
Bodø/Glimt barely missed out on the Champions League and instead fell to the Europa League, where they take on Portuguese giants Porto.
Ferencváros take on Belgian side Anderlecht to kick off their run in the new-look Europa League as they look to create an early shock.
Dynamo Kyiv and Lazio clash to open the Europa League, with all three points crucial for either side looking for a fast start.
PAOK and Galatasaray face off in the opening match of the league stage in the new format Europa League in Turkey.
Ludogorets take on Slavia Praha to kick off their run in the Europa League, with an early three points crucial for both clubs in the league stage.