When a ravaging plague, "The Purple Death", strikes the Earth, it is believed that Ming the Merciless is behind it and Flash starts off for Ming's headquarters to begin one of the most devastating battles of his career.
Using Ming's own weapon against Ming himself, Flash succeeds in aiming the deadly Solarite ship toward the enemy tower bringing about the fiery doom of the evil emperor.
While on the fateful mission to bring back the antidote to the Purple Death, Polarite, Flash and his party are attacked by the "walking bombs", an army of mechanical men.
After gathering enough Polarite to counteract the death dust of the Purple Death, Flash rescues Dale and Dr. Zharkov from a destroying ray as they return to Earth.
Flash returns to Ming's palace and successfully rescues Dale and Dr. Zharkov only to find that they are being attacked by Prince Garin who mistakes them for his enemy, Ming.
With the aid of Dr. Zharkov's new thermal control construction, Flash attempts to disengage one of Ming's fiery projectiles which threatens to destroy Prince Barin's kingdom.
Buster Crabbe
Flash Gordon
Carol Hughes
Dale Arden
Frank Shannon
Dr. Alexis Zarkov
Charles Middleton
Ming the Merciless
Roland Drew
Prince Barin