In Yokohama, vampire hunter Blade attacks a vampire feeding ground, which is camouflaged as a nightclub and acts as a front for the Asian vampire group, Existence.
Sakomizu, a middle-aged police detective in Osaka, is troubled by a recent series of missing Southeast Asian women. After he meets up with Blade, they discover that the chief of police is helping to provide local vampires with human blood.
Aboard a cargo ship heading for the Philippines, Blade departs Kobe Harbor hot on Deacon Frost's trail.
Determined to rescue his mentor, Van Hesling, from the clutches of a pack of Mandurago vampires, Blade tracks him to a local slum in the Philippines.
Siquijor Island, the location of an Existence research facility, is home to the Berdugo tribe who have used white magic to keep vampires under control since ancient times. Against the wishes of the Berdugo, Blade and Makoto set out in search for Frost's facility.
In his quest for Frost, Blade travels to the Island of Sumatra in Indonesia and launches an attack on a silver mine operated by Existence.