Refusing to accept that their crazy days are behind them, Jess and Cece abandon their low-key bachelorette party plans and seek a night out to top all others.
Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Coulson and the team can save them before the clock ticks out.
Willis and Campbell are sent to a Russian submarine in U.S. waters to treat a sailor badly wounded during an explosion, and violent convicts injured during a prison riot descend upon Angels Memorial.
The team searches for a suspected war criminal hiding in Los Angeles under a false identity.