A man is found handcuffed and stabbed in his hotel room, while a prank at the lab causes a rift in the CSI team and threatens their investigation.
The CSIs are called to three different crime scenes in one night that are seemingly unrelated, but each case's forensic evidence reveals a common link. (TV-14)
Christian searches for immortality and Kimber reacts to the news of Liz and Christian getting married. Katee Sackhoff, Annalynne McCord and John Schneider guest star.
The team is called in when an up-and-coming executive at an upscale clothing company is abducted from a taxi after attending a rooftop party in Manhattan. Meanwhile, Clark Medina (recurring guest star Steven Weber) continues to make his presence known as new head of the Missing Persons Squad.