When Dr. Alicia Seberg, a government research scientist (guest star Amy Price-Francis), is exposed to a deadly toxin while at work and has only hours to live, she calls Patrick Jane and the CBI to find her murderer.
A boxer's death leads Vance to start up his own investigation, causing a sparring match with Gibbs.
Residency Director Dr. Leanne Rorish (Marcia Gay Harden) puts her four new first year residents to work immediately on their first day at Angels Memorial Hospital, in the busiest, most notorious hospital ER in the nation.
After Christa saves a woman's life, she pleads with Neal to perform a surgery that will ensure the patient's reproductive future. Also, Mario gets into a fight with a patient after he delivers a diagnosis that could imperil the man’s hockey career.
Angus uses his background in psychology to help a woman who doesn't remember how she injured herself and others. Also, when Christa bonds with an illegal immigrant whose son is diagnosed with cystic fibrosis, she becomes determined to help the woman find long-term care for her son in the U.S.