As Jordan (Jill Flint) faces suspension for ignoring a religious patient’s “do not treat” directive, a military training accident makes Drew (Brendan Fehr) directly responsible for a fellow soldier’s life.
Topher takes over as chief of the night shift in the Season 2 opener. Also: TC is temporarily suspended; Jordan is scrutinized for her mishandling of the man who shot a recovered Topher; a father is trapped under an elevator; Ragosa returns to the ER.
A shooting sends two of Drew's friends to the ER. Meanwhile, a woman's psychosis worsens, becoming a danger to herself and her father; Paul breaks hospital rules to treat a 9-year-old boy with severe cystic fibrosis; financial problems plague Ragosa.
A downtown gas explosion sends dozens of casualties to the hospital. TC, Drew and Gwen scramble to the chaotic scene as Topher leads the team at the hospital. Meanwhile, Paul delves into his first night in surgery rotation while dealing with the unexpected arrival of his neurosurgeon father.
Mary and Marshall try to help FBI Agent Mike Faber convince his informant to enter Witsec. Despite their best efforts, the informant refuses their protection and gets himself into a heap of trouble. Meanwhile, Stan has to deal with an ex-boxer/witness suffering from pugilistic dementia. Guest starring Steven Weber.