The residents and interns treat the victims of a massive explosion at an apartment building, while Alex investigates the cause of the accident.
Kelly's obsession with her weight leads to an addiction to diet pills that puts her health in imminent danger. Her friends plan a surprise party for her 18th birthday but the pills make her so paranoid that she thinks everyone is against her.
As news of Daphne's past sends Charlie looking for her, an attack on Ned lands Griffin in jail; Bailey is offered a lucrative partnership in a chain of restaurants.