An erroneous report that Frasier has died motivates him to do a makeover on his life.
Derek searches for the best way to propose to Meredith; Callie tries to convince Mark not to blow his chance at real love with Lexie, despite his fear of Derek finding out; Izzie learns she has anemia.
Tragedy strikes when Derek loses a pregnant patient with an aneurysm during surgery and Addison must deliver the premature baby; Izzie learns she does not have anemia as she first thought, but something much worse.
As Ally, Cage and Georgia try a case about liability in an airplane crash, Ally is reunited with male model Glenn, her recent one-night-stand, who makes her feel guilty about using him as a sexual object.
Grissom and his team battle the flu when they are called upon by DDA Klein to investigate the deaths of several key witnesses for a grand jury case against a dangerous Las Vegas gang. (TV-14)