Sophie Thatcher

After a luxury condo is robbed, the team is shocked to learn that not only was the family fast asleep when the crime occurred, but their teenaged daughter was violated during the invasion as well. Voight (Jason Beghe) consults Jimmy (guest star Steven R. McQueen) from Firehouse 51 to confirm his suspicion that the family was knocked out by a powerful gas, and Lindsay (Sophia Bush), Halstead (Jesse Lee Soffer), Atwater (LaRoyce Hawkins) and Ruzek (Patrick Flueger) go undercover to seek out the perpetrators. Meanwhile, Voight tries to help a former acquaintance get back on his feet, and Platt (Amy Morton) and Mouch (guest star Christian Stolte) receive disappointing news regarding their upcoming wedding.

After discovering that a patient's family might have been abusive, Dr. Choi (Brian Tee) and April (Yaya DaCosta) contemplate calling child services. Dr. Manning (Torrey DeVitto) and Dr. Halstead (Nick Gehlfuss) struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes (Colin Donnell) is persuaded into preforming a risky surgery on Dr. Bekker's (guest star Norma Kuhling) mentor and world renowned surgeon, Dr. Marvin Jaffrey (guest star Malcolm McDowell). Meanwhile, Dr. Reese (Rachel DiPillo) joins Dr. Charles (Oliver Platt) on a visit to the Cook County jail.

Upon hearing news of a pregnant teen, Dr. Manning (Torrey DeVitto) and Dr. Choi (Brian Tee) venture to a homeless encampment to help deliver a baby under dire circumstances. Dr. Rhodes (Colin Donnell) and Dr. Bekker (Norma Kuhling) argue about the best way to treat a young boy with a chronic disease. Dr. Halstead (Nick Gehlfuss) and April (Yaya DaCosta) are put in an uncomfortable situation when they find out their patient is a pedophile. Goodwin (S. Epatha Merkerson) and Maggie (Marlyne Barrett) have to deal with a lawsuit against the hospital. Dr. Charles (Oliver Platt) learns of important news pertaining to Dr. Reese's (Rachel DiPillo) father (guest star Michel Gill).

After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father (guest star Michel Gill).

As Marcus, Tomas and Mother Bernadette race against time to defeat the demon, the Rance family finds itself drawn into the conflict. With the Pope’s visit only days away, the church’s enemies take aggressive new moves. Angela confronts a familiar face from her past, and Kat considers a new future.