With solo surgeries for the residents pending, the interns and residents scramble for practice and a way to prove themselves.
Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.
A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.
As Adele's condition deteriorates, Richard considers making a change; an explosion at a coffee shop results in a busy ER; Callie helps Meredith study; Lexie helps Alex and Arizona care for an intern's premature baby.
Cristina makes Owen tell her about the intimate details of his affair; Mark takes his authority very seriously when he steps in as chief for the day; Arizona, Callie and Bailey plan special night for Teddy.