Susan takes the escape into her own hands, leaving Michael's life hanging in the balance; Lechero reveals a secret buried beneath Sona; Sofia uncovers more of Whistler's past; Mahone's freedom hinges on his testimony; and Lincoln and Sucre are targeted by The Company.
Walker breaks in a new partner while protecting Alex from an ex sheriff turned prisoner who blames Alex for putting him in jail and seeks revenge.
Walker and Trivette, despite having no jurisdiction, travel to Mexico to rescue a captured D.E.A. agent, who is an old friend of Walker, from a Mexican drug cartel.
When a protected witness is killed while Walker and Trivette are guarding him and a mobster may be released from prison as a result, Walker goes undercover as a convicted assassin in the maximum security prison to force a murder confession from the mobster.
Alex receives a lucrative job offer from a large law firm in Dallas, but on her way to the interview, she and the firm's owner are kidnapped, and Walker and Trivette must find them before the outrageous ransom is exchanged and Alex is killed.