Sean McDermott

A young boy needs a heart transplant but doesn't seem to want it, and his treatment causes Burke and Yang to have philosophical differences. Meanwhile, when the interns rally to help Alex prepare to re-take his exam, Meredith has to remind Izzie of the true spirit of the Christmas holiday; and despite a reconciliation with his wife, Derek isn't in a festive mood.

After she discovers Islam, Williams tries to change herself and other deputies.

When her parents come for a visit, Billie accidently transforms them into assassins and also manages to contact a demon who is posing as a human.

When a pizza deliveryman mistakenly gives Natalie $50 in extra change, Natalie decides to do a good deed. She follows him, intending to return the money, but is shocked to find his car on a deserted street, with the deliveryman beaten to death in the driver’s seat. Stottlemeyer and Disher arrive to assess the situation, but they’re soon called away to a bigger case. With the authorities distracted, Natalie feels obligated to champion the cause of the dead deliveryman. She goes to Monk for help, but he’s feeling sick, and soon finds himself stuck in bed with the flu. Natalie is now on a mission to get to the bottom of things.

Allison tries to help Devalos solve the recent murder of his friend's sister, but her dreams keep pointing to the friend's first husband, Nathan, who died in a car accident two years ago.