Joe and Marybeth try to reconnect as Joe is shut out of the murder investigation. Nate and Cricket seek answers to past secrets while on the run.
When the team treats a patient who has to decide between a dangerous surgery that could change his life or remain the same, he asks Dr. Shaun Murphy what he would if he had that same choice.
A Secret Service agent ends up questioning his own sanity as he searches for two missing colleagues in a strange town that he seemingly can't escape.
In Camelot, as Mary Margaret and David attempt to retrieve the Dark One dagger, Emma uses a dreamcatcher to look into the past to see how Merlin was transformed into a tree. Together, Emma and Regina figure out the critical ingredient they must acquire to free Merlin, but it's a race against Arthur, who does not want Merlin released.
Kiera's developing relationship with the mysterious John Doe causes tension in her role with the Freelancers, and a change in her view of the world. Alec's newest invention is set to change the world, but questions are raised about its safety by a newly-lucid Jason. Carlos and Kiera join with Alec in finally putting the 'other her' to rest...but Kiera makes a discovery that turns her attitude toward Alec on its ear.