Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Jo and Alex's honeymoon doesn’t go exactly as planned.
Seattle firefighters Ben Warren and Andy Herrera head to Grey Sloan after rescuing two boys that are injured in a house fire. Meanwhile, the doctors are hard at work on their projects for the Grey Sloan Surgical Innovation Contest; and Amelia brings Tom Koracick in to consult on her and Alex's patient.
Meredith works on a patient who happens to specialize in matchmaking, and a seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve. Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life.
Maggie and Jackson are enjoying spending time together, but he must turn his concentration toward the groundbreaking vaginoplasty surgery he has scheduled with Catherine and Richard. Meanwhile, Meredith and Jo hit a roadblock with their contest submission, so Jo helps Bailey with an incoming trauma patient who used to be an astronaut.
The hospital brings in crisis management to help them sort out allegations against Harper Avery. Meanwhile, Nurse Olivia shows up at Grey Sloan with her son, throwing Alex and Jo for a loop; and Arizona decides to spend more time with Sofia who is having a hard time at school.
