Freya relives one of her past lives with Killian. Dash does a spell at work without realizing the consequences. Joanna seeks the help of an old friend, Alex. Wendy and Freddie work together to try and stop the Mandragora while Ingrid’s bond with it grows stronger.
Jack desperately tries to find Amy in Seattle but her movements offer more questions than answers; Madison finds herself in a train station with a ticket to Seattle, an envelope of cash, and a mysterious key. An act of humanity has serious consequences for Richard.
Jack returns home to find Amy sleeping soundly in bed. She has a logical explanation for her whereabouts in Seattle and professes her love to Jack only to ask for a separation the next day. Jack is terrified for Amy's mental state. Meanwhile, Gary calls with alarming news. Things get dangerous as Madison hitches a ride to Seattle, determined to evade capture.
When multiple patients of grief counselor Mia Vallens (guest star RUKIYA BERNARD) turn up dead, Sam, Dean and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
