Roxanne Hart

When a high school student falls victim to a mysterious but lethal poisoning, House and his team jump in to find out what is killing the teen. Given a low heart rate and a clean tox screen, House sends Cameron and Chase to the teen’s home to find the hot new drug House is sure he’s taking. They don’t find any drugs, but think they’ve come up with the answers, until a second unrelated student is admitted with identical symptoms. With the boys’ lives hanging in the balance, House and the team have to connect the dots - fast. Meanwhile, an 82-year-old patient has become enamored with House while he helps her figure out the basis of her renewed fascination with her sexual feelings.

The BAU investigates a series of deaths involving possible exorcisms in the Washington area that appear to be sanctioned by the Vatican, and SSA Emily Prentiss finds herself personally involved in the case.

The decomposed skeleton of what appears to be a young girl is found in a grocery cart in the D.C. area. Angela's reconstruction based on the evidence reveals the face of an 80-year-old woman, not a child, but the team learns the victim actually was a 22-year-old woman with a debilitating aging disease. Brennan and Booth's investigation leads them to the victim's mother, who points a finger at a former caretaker. But without a definitive lead, the team searches to find out who would want to take this defenseless woman's life, and the case strikes an especially emotional chord with Brennan. Meanwhile, Brennan's father, Max Keenan (guest star Ryan O'Neal), reappears in Brennan's life in an attempt to make a connection with her and deliver information from her past, and she's surprised by her reaction. Hodgins and Angela walk down the aisle with Brennan and Booth as maid of honor and best man, respectively, but all does not go as planned.

Cristina meets Burke's parents -- and in the most awkward of circumstances -- the interns campaign for Izzie's reinstatement to the surgical intern program, Addison takes a break from her hospital duties, and a surgical patient lives what may be her last day to the fullest.

Jane agrees to assist FBI Agent Susan Darcy with a murder investigation, even though he suspects that she has an ulterior motive in wanted his help – to probe him about Red John.