Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital's surgical unit.
Peter, Olivia and Walter come face-to-face with a mysterious and terrifying Fringe event as they become trapped in a town there's no escaping from.
After Zatanna sends a magically spiked bottle of champagne to Clark and Lois for their bachelor/bachlorette parties, the gang blacks out after the toast, only to wake up the next morning and realize they can't remember anything about the night before.
After her old friend, Garrett Burke, is killed in Bucharest, Sydney receives a mysterious package sent before his death.
In Chicago, MacGyver tries to help Roxy, an old friend, during her shoot of a Rock Against Drugs video. She believes her twin sister is trying to kill her, fueled by jealousy over her music career.
