Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital's surgical unit.
Peter, Olivia and Walter come face-to-face with a mysterious and terrifying Fringe event as they become trapped in a town there's no escaping from.
After Zatanna sends a magically spiked bottle of champagne to Clark and Lois for their bachelor/bachlorette parties, the gang blacks out after the toast, only to wake up the next morning and realize they can't remember anything about the night before.
In Chicago, MacGyver tries to help Roxy, an old friend, during her shoot of a Rock Against Drugs video. She believes her twin sister is trying to kill her, fueled by jealousy over her music career.
Liam (Robert Leeshock) and Renee (Jayne Heitmeyer) find themselves in a life-and-death situation when they try to rescue the pregnant Lili (Lisa Howard), who has returned to Earth determined to give birth to her human/Jaridian hybrid baby.