The BAU is called to Dallas to investigate when a serial killer lures and kills high-powered executives by posing as a high-class call girl.
Costumed patients create a challenge for the doctors; Derek and Ben work on a new surgical technique; Richard asks a resident to perform his next surgery, angering Bailey.
Don and the team investigate the secret world of alternate-reality games after a man plunges to his death while participating in one such game. Amita's life is in danger when her hidden gaming ability becomes the key to tracking down the killer.