Medavoy and Martinez investigate a shooting at a bodega, which they suspect is just a front, and Sipowicz and Simone try to track down the killer of two victims gunned down in their car.
The CSIs must investigate when a pedestrian is killed after a man falls from a building and lands on him.
Brenda feels betrayed by Kelly's decision to audition against her for the lead in the play and refuses to speak to her former best friend. Meanwhile, Dylan's deepening relationship with Suzanne puts strain on his romance with Kelly.
When Julie overdoses on drugs prescribed by Dr. Lester, Hoffman suspects the doctor has ulterior motives for keeping his female patients so heavily sedated.