A religious sect member capable of changing gender becomes the prime suspect in a murder spree.
The agents face their old foe, Alex Krycek, while pursuing a radioactive entity unleashed from a sunken WWII wreckage.
While helping the People's Republic of China secure a priceless national treasure - The Ming Dragon - in a San Diego museum, MacGyver runs into a Lisa, a woman that he had loved and thought was long dead.
The KBG have Lisa in their grasp, and to free her MacGyver must get The Ming Dragon for them.
The Phoenix Foundation takes on the decommissioning of nuclear missiles. When the process goes awry and an explosion kills three people, Pete blames himself for not inspecting their equipment better and resigns from his job out of guilt.