While the pressures of being in space starts to take its toll on Howard, Amy feels threatened when Sheldon hires a young female assistant, Alex (guest star MARGO HARSHMAN).
When Howard returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.
On the sixth season premiere, Howard discovers that he can't escape his mother – even in space! Caught in an argument between Bernadette and his mom (recurring guest voice CAROL ANN SUSI), Howard deals with woman trouble from the International Space Station. Back on earth, meanwhile, Raj faces his loneliness, by turning his existence as a third wheel into an art form.
When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. But Sheldon is no good at keeping secrets. Meanwhile, Howard is being picked on in space by the other astronauts (guest stars PASHA LYCHNIKOFF and MIKE MASSIMINO).
Howard Wolowitz crosses over into the final frontiers of space…and marriage on the fifth season finale. When Howard and Bernadette decide they want to be married before his NASA space launch, the gang rushes to put on a wedding. NASA Astronaut Mike Massimino guest stars as Himself.
