As Shaun (Freddie Highmore) and Claire (Antonia Thomas) improvise to preserve a liver for a transplant, Andrews (Hill Harper) is pressured to partner with Melendez (Nicholas Gonzalez) on a wealthy patient’s routine surgery.
Melendez (Nicholas Gonzalez) takes a risk to save a mother and her unborn child, placing the hospital in legal jeopardy. As Shaun (Freddie Highmore) struggles to adjust to his new life, he and Claire (Antonia Thomas) team up to treat a teenage porn actress.
During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.
Shaun and Melendez team up to devise a heart surgery to save a gravely ill African boy. A missing tissue sample leaves a young mother facing potentially unnecessary surgery.
Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins whose lives intersect in more ways than one. Meanwhile, overwhelmed by Dr. Aaron Glassman's attempts to have him meet with a therapist and the demands at work, Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave everything behind.
