Noel Conlon

When Henry (guest star Howard Hesseman) experiences a seizure but is not aware of it while it’s happening, House takes on the case. The team’s differential diagnosis points to a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work, prompting the need for a heart transplant. Racing to find a heart donor in time to treat Henry before the infection kills him, House finds an organ donor who’s been declared unfit due to a mysterious illness.

Tension builds as Mel subjects Niles to social humiliation before she will grant him a divorce.

A whacked-out Grace (Debra Messing) is wracked with guilt over the death of a high school classmate whom she once tormented, so she drags Will (Eric McCormack) along to the funeral - and gets the surprise of her life - while Will offers a sympathetic shoulder to a handsome grieving relative (guest star Todd Stashwick). Elsewhere, an ecstatic Jack (Sean Hayes) asks Karen (Megan Mullally) to accompany him when he is nominated for a lower Manhattan, non-transgender Equity Waiver gay cabaret award.

Nick defends a sexually abused teenage boy who wants to protect his father from being implicated in the crime, even though it appears that his father was the abuser.

Merle's sister, Linda Mae, comes for a visit.