Sean Lock and David Mitchell face team captain Jon Richardson and Sara Pascoe. "Mum's the Word" comedy duo joins Susie Dent in Dictionary Corner.
Karry Godliman is the guest team captain, joined by Nish Kumar, Natasia Demetriou, Fred Sirieix and Judi Love.
Jimmy Carr hosts a brand new series of the topical comedy panel show discussing the nation's most popular talking points.