When the prolific serial killer Frank returns and murders Gideon's girlfriend in his own apartment, he starts his own investigation.
The team believes a patient's problems are both physical and psychological; Foreman tries an alternative approach with House.
Lightman is brought in to investigate a building collapse.
Bob is held hostage by a drug cartel after he poses as a chemist who can turn cocaine into paint for easy smuggling. Meanwhile, Mack penetrates the group posing as a prize fighter in an illegal betting ring to help bring them down.
Matt Saracen (Zach Gilford) reaches a tough point in his life where nothing seems to really matter to him anymore. Meanwhile, Tami Taylor’s (Connie Britton) relationship continues to grow with Tyra (Adrianne Palicki) and Julie (Aimee Teegarden) becomes very jealous. Landry (Jesse Plemons) may have a new potential love interest that could shake up his relationship with Tyra. Elsewhere, Brian "Smash" Williams (Gaius Charles) begins his three game suspension and turns to Coach Taylor (Kyle Chandler) for advice.
