Clark and Lex team up to rescue members of Clark's high school class after a janitor, Earl Jenkins (Tony Todd), takes them hostage in LuthorCorp's Smallville Fertilizer Plant No. 3. Jenkins claims his deadly "jitters" were caused by a mysterious contaminant, and he threatens to kill everyone unless he is shown a secret sublevel -- which Lionel Luthor (recurring guest star John Glover) denies ever existed.
After learning that Jason and Lex are in China searching for one of the mysterious crystals, Clark and Lana follow in the hopes of finding one first. Clark discovers an artifact that leads them to the crystal, but he must battle Isobel, the witch, who has once again inhabited Lana's body in order to take the crystal for herself. Meanwhile, Lex knows more about the crystals than he admits.