A hostile government forces a family to go on the run and fights to survive.
Lincoln must say goodbye to yet another loved one as he attempts to reunite with Michael; Michael's attempt to secure a getaway plane is grounded; Mahone deciphers a crucial puzzle piece; T-Bag gets his revenge on his tormentors; and Sara and Kellerman have a tense face-off that leaves one of them gasping for their last breath.
A would-be Texas Ranger, obsessed with Walker's exploits, tries to outdo him by wreaking vengeance on every escaped criminal in town, along with any innocent people who happen to get in the way.
Mary is forced to be a reluctant go-between in the WITSEC version of a witness Romeo and a suspect Juliet.
After a wilderness leadership trip takes a dark turn, Walt and the team must track down a killer and missing teenaged campers. Branch, meanwhile, continues his unsanctioned pursuit of his shooter.