Sikowitz challenges the students to say yes to everything for one week. The gang agrees, and they soon find themselves out of their respective comfort zones.
When Mindy's old flame Casey (Anders Holm) returns to New York, Mindy is confronted with the dangerous temptation of sliding back into a relationship with an ex-boyfriend.
The team finds good news after a murder in that there is a witness. The bad news is the witness suffers from Prosopagnosia, commonly known as facial recognition blindness, and can’t recognize the killer. The Rizzolis prepare for a visit from a scheming cousin.
When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.
