When Detective Bell's girlfriend, Chantal (Chasten Harmon), is assaulted and her ex-husband is killed soon after, in what Holmes and Watson discover is a staged suicide, they search for one suspect behind the linked crimes. Also, as Bell fights the urge to seek his own brand of justice for Chantal, Sherlock makes a heartbreaking realization about the detective's past.
Jackie goes undercover as an escort when she and Danny track down a serial killer who is murdering prostitutes in hotel rooms. Meanwhile, Erin meets a potential suitor at an art gallery who shares her interests.
When Erin's informant is murdered, she blames herself and works to help Danny discover who killed him.
Unleashed by animal activists, a scientifically engineered beast with a ferocious appetite attacks Charlie. Walter must now come face-to-face with both his past and the creature.
After having her heart broken, Newberg's stepdaughter lands in the hospital with a condition directly related to her relationship woes. Divya attempts to bring romance into her relationship with Raj. Henry Winkler guest stars.