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On the season eleven premiere, with Cristina gone, a new doctor, Maggie Pierce, making the rounds, and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina's board seat and a freak accident causes two teenagers to be caught in a very compromising position.

Carly decides to do a webcast showing what mean teachers do when they're not in school. They decide to follow their mean teacher but find themselves in serious trouble when they accidentally get trapped at her apartment.

Will's first day working for the occupation brings unforeseen challenges. Katie commits herself to the Resistance and receives her first assignment. Maddie reconnects with an old acquaintance. Carlos pays the price for Will's collaboration.

Katie's first mission leads her to question her commitment to the cause. Will's hunt for Geronimo draws him into the Resistance's crosshairs. Bram's girlfriend needs him to keep a secret.

Geronimo's identity is revealed. Will begins to question his wife's loyalties. Katie struggles with the weight of her choices. Bram finds his way into a secret world. Snyder sees an opporunity to improve his standing in the colony.