MacGyver faces off with a cunning new adversary whose carefully crafted plans put Mac at the epicenter of an impossible choice: save the life of a friend, or save the lives of hundreds of innocents. Also, Mac receives new information that will drive a wedge between him and his father.
When two American tourists go missing while doing a 'No-Go Scavenger Hunt' through some of the world's most dangerous countries, the Phoenix team goes undercover as backpackers to find them and bring them home alive.
The Phoenix must recover the body of a pilot whose plane crashed while testing an experimental laser mapping system that MacGyver designed. Also, Riley tries to identify the hacker who tricked a SWAT team into arresting her and Elwood.
MacGyver and team are asked to solve a locked-door mystery when a man working inside a remote, ultra-secure international seed vault disappears.
When Nicholas Helman (Michael Des Barres) resurfaces to carry out a killing spree, the Phoenix is forced to get help from the one person who knows him best... his protégé, Murdoc.