Frank enlists the help of an old friend, Sloane Thompson (Alex Kingston), to investigate a cyber-attack on the NYPD that forces Danny and Baez to release an evasive suspect. Also, Baez questions her place within the NYPD.
An explosion at a wedding ceremony sends a stream of injured partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries. While helping a young girl out of a catatonic state, Iggy learns the truth about the wedding.
In the series finale, everyone's story reaches a surprising yet inevitable conclusion.
Max discovers the extent to which Dr. Fuentes’ cuts are severely damaging New Amsterdam and decides it’s now or never. Iggy takes an unconventional approach to reach a young patient in need. Reynolds and Wilder perform a risky, life-saving surgery on unborn twins.
The COO of a major tech company is found murdered in Central Park. Price and Maroun work to untangle a web of deceit to expose a cunning narcissist.