An alien race known as the Xindi launch an attack on Earth, causing great casualties and massive damage. As Enterprise heads back home, an unlikely source informs Archer about the Xindi and that their next attack will destroy Earth.
George puts his stamp on the Fisher home. David cautions Nate about projecting his personal grief onto their clients; Keith applies for a glamorous new job; Joe challenges the logic of Brenda's 12-step plan; Claire reawakens her artistic muse after meeting a free spirit named Edie; and Federico proves that charity doesn't always begin at home.
Sipowicz and Sorenson investigate the murder of a drug dealer, while Sorenson continues to see the stripper, Kristen, who draws him into a favor for the owners of the Tailfeathers club.