Sybil (guest star Nathalie Kelley) enacts revenge on Damon (Ian Somerhalder) by putting him in a catatonic state. Caroline (Candice King) and Bonnie (Kat Graham) enter Damon’s mind and run into familiar faces from the past, only to discover Stefan (Paul Wesley) is the key to Damon’s fate. It’s a race against time for the bell as both Sybil and her sister Seline (Kristen Gutoskie) jockey for its control. Zach Roerig also stars.
Severide and Violet risk clashing with Paramedic Chief Robinson after Lennox makes a dangerous decision on a call. Capp and Tony attempt to break a world record. Cruz and Chloe's marriage problems come to a head.
Firehouse 51 is faced with a daunting challenge when an out of control blaze consumes a 15-story apartment complex, trapping victims on the top floors. Complicating the rapidly escalating situation, members soon discover that someone close to home may be one of the trapped victims.
Firehouse 51 deals with the aftermath of the capsized boat rescue. Gallo, Ritter and Violet discuss plans for a side gig.
In the first part of a three-show crossover event, a rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago's finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening
