Charles asks Jake to be the best man at his wedding, a role that requires Jake to be supportive in important wedding decisions, ranging from cake tasting to floral arrangements. Meanwhile, Terry, Amy and Gina support each other as they start a new extreme diet and Holt helps Rosa make a sincere apology.
When extremely educated new intern Dr. Oliver Wells (guest star Brian Klugman) starts working at the Jeffersonian, his quick-learning, enthusiastic personality challenges Brennan as he gets under her skin with his eccentric but undeniable observations, causing her to try to be more open-minded about many scientific questions. Meanwhile, Booth worries she may have gone too far when she accepts the possibility of time travel as a factor in a murder investigation.
Alicia's professional future hangs in the balance as she decides what's next for her career. Meanwhile, when Alicia gets a suspicious call from a client, she discovers that he's being held in a secret police facility where people are detained without being officially booked.
A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.
Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.
