Keri Lynn Pratt

When Henry (guest star Howard Hesseman) experiences a seizure but is not aware of it while it’s happening, House takes on the case. The team’s differential diagnosis points to a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work, prompting the need for a heart transplant. Racing to find a heart donor in time to treat Henry before the infection kills him, House finds an organ donor who’s been declared unfit due to a mysterious illness.

Emily Prentiss and Jordan Todd go undercover in Atlanta to profile a serial killer who has perfected his skill as a pick-up artist and uses his masculine prowess to lure his next victims.

After Booth has a bedroom romp with his ex-girlfriend Rebecca, he gets a call from Brennan about their latest case and agrees to meet her at a condominium construction site. They're led into a partially built unit where they find the gruesome remains of a man dissolving in a bathtub of household cleaning products. After determining the victim had Brittle Bone Disease, they search a database of area BBD victims, all of whom are children, and split up to visit them in hopes of finding a connection to the dead man. When both Brennan and Booth come back with confirmation of the man's identity, they realize he was living a double life with two different families. In what first appears to be a straightforward case of jealousy and insurance money, new clues send Brennan and Booth in a completely different direction and a third suspect is brought to light.

Annie Potts, Fred Thompson and Judith Light guest-star--When Lauren Westley (guest-star Keri Lynn Pratt) is found badly beaten and taken to a New York hospital, it is discovered she's a runaway from Virginia whose father Philip Westley (guest-star Skipp Sudduth) has been in the city searching for her. Detectives discover that Westley was 24 weeks pregnant and due to her injuries, suffered a miscarriage. As the investigation unfolds Detectives Benson (Mariska Hargitay) and Stabler (Chris Meloni) question Wayne Meredith (guest-star John Patrick Medori) a teenager from Westley's high school who is the father of the baby. Westley and Meredith ran away to New York seeking the help from an abortion clinic. When the case goes to court, Meredith's attorney, Sophie Devere, (guest-star Annie Potts) tries to defend Meredith's actions but new evidence is introduced questioning the credibility of the abortion clinic and whether the doctor there was ultimately responsible for West's injuries. Fred Thompson, Judith Light, Diane Neal, Richard Belzer, Dann Florek, B.D. Wong and Tamara Tunie also star.

The case of a murder and a missing person on an intensely guarded wealthy family's compound perplexes Patrick Jane and the CBI team.