Kai Lennox

An out-of-this-world case brings Brennan and Booth to New Mexico where they investigate human remains with extraterrestrial attributes. The victim is identified as a local UFO fanatic, known around town for her relentless search for alien life forms and whose latest “evidence” leads even Brennan and Booth to re-think outside existence. Meanwhile, a local sheriff refuses to release the bones, forcing the team at the Jeffersonian to work via satellite, and Angela and Jeffersonian intern Wendell (guest star Michael Grant Terry) come clean about their relationship.

Derek and Addison Shepherd's professional relationship is challenged when their closest friends come to Seattle Grace seeking a radical, preemptive operation to avoid breast and ovarian cancer. Meanwhile, George can't understand why a patient who fell five stories doesn't seem happy to have survived; an elderly gentleman makes a difficult decision upon learning that his wife has only a few months to live; Cristina and Burke try to have a "normal" date, and Chief Webber is disappointed by Bailey's fellowship decision -- until he learns her reasons.

The team treats an underage and homeless female patient (guest star Bridgit Mendler), but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient's mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman's relationship with a married woman (guest star Yaya DaCosta).

After a petty officer dies in a car crash, the team suspects foul play when their investigation leads them into the violent world of underground street fighting.

Castle is captured and forced to work with strangers to solve deranged puzzles and mind games, while Beckett and the 12th Precinct race against time to rescue Castle and catch a killer.