When Coulson and the team discover a new Inhuman, S.H.I.E.L.D. comes face to face with another organization searching for powered people. And still reeling from Simmons' dramatic disappearance, Fitz goes to extreme lengths to try to learn how to get her back.
Ward's campaign for revenge brings the S.H.I.E.L.D. team to their knees, and Coulson proves he will do anything to settle the score.
Coulson is determined to get to Gideon Malick and put an end to Hydra once and for all. Meanwhile, Daisy and the team encounter more Inhumans who have powers they've never seen before.
As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their biggest foes. Meanwhile, Fitz helps Simmons recover information that could lead them back through the portal.
S.H.I.E.L.D. and Hydra go head-to-head in a battle that will change Coulson's world forever. While Daisy and her team of Inhumans fight to keep Hydra at bay, Coulson and Fitz take the ultimate risk, in the epic winter finale.
