Joseph Lyle Taylor

Just before mobster Joey Arnello spills the beans in federal court and enters witness protection, he collapses. Is he faking? A court order instructs House to find out - and fast. House and his team struggle to diagnose and cure Joey while Joey’s brother Bill tries to slow things down and keep Joey from testifying. Meanwhile, Cuddy struggles to convince Vogler (guest star Chi McBride) that House is an essential part of the hospital. With Joey mysteriously slipping in and out of a coma, and House’s job on the line, House makes an exception to his own policy and gets to know his patient.

A going-away party for a bank manager turns into an emergency, and then a mystery, as the first responders are accused of pulling off a daring heist.

Construction workers discover a teenage girl, Tandi McCain (Amanda Seyfried), who's been missing for days, bound with duct tape and very scared. She was apparently raped, but when her stepfather, Ronald (Michael O'Keefe), arrives, they fight to prevent her from going to the hospital. Benson (Mariska Hargitay) convinces them they have no choice in the situation. Tandi had definitely been raped, and claims she was on the Hudson University campus, when four cadets kidnapped her and took her. She is a little sketchy with the descriptions, but the detectives are able to identify four cadets who all have the same story - Tandi had been at a dorm party, drinking and having a good time. They all claim innocence, and continue to stick by the fact none of them touched her.

Derek and Addison Shepherd's professional relationship is challenged when their closest friends come to Seattle Grace seeking a radical, preemptive operation to avoid breast and ovarian cancer. Meanwhile, George can't understand why a patient who fell five stories doesn't seem happy to have survived; an elderly gentleman makes a difficult decision upon learning that his wife has only a few months to live; Cristina and Burke try to have a "normal" date, and Chief Webber is disappointed by Bailey's fellowship decision -- until he learns her reasons.

A starving toddler found wandering the streets alone leads detectives to the home of Manuela Ozuna (guest star Jessica Pimental) and another child in grave condition. The police question Department of Child Services caseworker Keith Musio (guest star John Magaro), whose vague and backdated reports on the family suggest he hadn't checked on the children in months. When the overworked Keith accuses his supervisor, Janette Grayson (Goldberg), of orchestrating the false reports, Chief Dodds (guest star Peter Gallagher) promises to conduct an internal investigation. But when neglect leads to death, Barba (Raúl Esparza) takes matters into his own hands and arrests them for manslaughter. Meanwhile, Dodds indicates some changes coming to Benson's (Mariska Hargitay) squad.