A couple travels across the ocean in search of a diagnosis from House.
The BAU travels to Oregon to assist local authorities in investigating the disappearances of people who are new to the city and have no strong social ties in Portland.
Thanksgiving with Marshall's family is especially stressful for Lily because she thinks she may be pregnant. Elsewhere, Robin, Barney and Ted spend the holiday volunteering at a homeless shelter.
An unexpected announcement at Gaby's engagement party; a dead body in a home on Wisteria Lane; Susan makes a choice between Ian and Mike.
Susan discovers revealing secrets about her future in-laws; Gaby has a devastating catastrophe; an unexpected love affair develops.
