House and the team treat a patient who speaks his mind uncontrollably; House thinks Taub and Wilson are keeping something from him.
The Jeffersonian team investigates the murder of a food scientist whose remains were tossed in a meat grinder and mixed into cans of stew served in a school cafeteria. When the team uncovers the scientist’s newest – and highly lucrative – food invention, they begin to track the trail of jealous competitors in the multi-million dollar food industry. Meanwhile, Angela plans a post-wedding bachelorette party for Brennan and it gets crazier than intended.
Meredith's dishonesty is revealed, leading to unexpected consequences for her and others; the new chief resident is chosen.
Doctor Cyril Taft (Jon Cryer) experiences the rush of an NCIS case after he is assigned surgical duty to Gibb's suspect and finds key evidence. Also, Dinozzo pays Jeanne Benoit (Scottie Thompson) a visit as he chases a lead involving doctors in Sudan. Laura San Giacomo Guest Stars as Dr. Grace Confalone.
A love triangle heats up among Marley, Jake and Ryder, and Blaine has a run-in with the Warblers. Musical performances include "Dark Side", "Superman", "Holding Out For A Hero", "Heroes" and "Some Nights".