Dr. Murphy becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; a male college student has a mysterious split personality disorder.
Frantic with worry about his gravely ill Grandpa Harry, an attack from a man who's stolen an ancient Egyptian relic leaves MacGyver in a coma, where he experiences a vision where departed family members teach him the value of life.
Vinnie has no choice but to come out from behind his OCB badge to face the chilling accusations of mobster Sonny Steelgrave—the friend he was forced to betray.