Frasier is more nervous than his son when Frederick competes in the National Spelling Championship, and the elder Crane ends up ruining everything for his offspring.
Someone from Derek and Addison's past arrives in Seattle and shakes things up. Meanwhile, Burke learns about Christina's secret and, after a visit with her mother, Meredith looks into more of her family's dirty laundry.
George begins to overstay his welcome at Burke's apartment; Meredith learns a secret about her father; Bailey worries her colleagues will not treat her the same now that she's a mother; and Alex gets a lesson in bedside manners.
The race for chief heats up after a new competitor enters the fray, tensions escalate between Izzie and George, and Callie must reveal a big secret. Meanwhile, Derek treats a patient near and dear to him, while Alex continues his work with Jane Doe.
After a successful operation on his heart, George's father undergoes surgery for his cancer, Thatcher Grey visits Seattle Grace in order to see his new granddaughter, and Meredith discovers that Derek has trouble sleeping soundly. This is Part One of a two-part episode.
