Jeff Doucette

In the aftermath of tragedy, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike Delfino's real reason for moving to the street, Lynette reaches the breaking point in her addiction to the twins' ADD medication, and the mysterious Mr. Shaw (guest star Richard Roundtree) gets down to business.

There's a change in Mama Solis' (guest star Lupe Ontiveros) condition as Lynette befriends a deaf woman, Alisa (guest star, Academy Award-winning actress Marlee Matlin), whose children also attend Barcliff. Bree encounters more trouble with son Andrew and Susan finds herself attracted to Edie's hunky new contractor (guest star Rick Ravanello).

Castle's agent, Paula Haas, approaches him with a career changing opportunity which would signal end of his relationship with Beckett.

Sheldon’s database invention puts him at odds with the university. Also, the church takes issue with Meemaw’s video store.

An exhausted Meredith thinks she may have made a mistake during surgery, which could jeopardize her career. Meanwhile Izzie’s plan to throw a party for her new boyfriend goes completely awry, and Alex deals with a patient who is addicted to painkillers.