Izzie decides to undergo cancer surgery; Mark prepares to move forward with Lexie; Bailey finds out if she gets a pediatric fellowship; the Seattle Grace doctors team up following a car accident.
The BAU searches for a motive and an UnSub when victims are found in truck stop restrooms along highways throughout the South.
Jane enlists his colleagues in a dangerous sting operation to catch a deadly team of art thieves. Meanwhile, sparks fly between Lisbon and an agent from the FBI's art squad – Marcus Pike (guest star Pedro Pascal).
When Castle's idol, a famously reclusive author, turns up dead, Castle is determined to solve his hero's murder. But as he and Beckett dig deeper, they discover that truth is stranger than fiction.
Addison puts the practice in jeopardy while trying to fix its financial woes; Sam and Naomi tell Maya they are back together even though they are not; Violet is asked to destroy the medical records of an old friend running for office.
