CSI: VEGAS opens a brand-new chapter in Las Vegas - the city where it all began. Facing an existential threat that could bring down the entire Crime Lab and release thousands of convicted killers back onto the neon-lit streets of Vegas, a brilliant new team of investigators led by Maxine Roby must enlist the help of old friends Gil Grissom and Sara Sidle. This combined force will deploy the latest forensic techniques to do what they do best - follow the evidence - in order to preserve and serve justice in Sin City. In the premiere episode, an attack on Jim Brass (Paul Guilfoyle) kicks off a twisted conspiracy targeting the Las Vegas crime lab.
As Grissom and Sara close in on who framed Hodges, the CSI team investigates a lock room murder mystery at 30,000 feet, when a cargo plane lands autonomously at McCarran Airport and everyone on board has been killed.
Max puts CSI on lockdown when evidence in a new murder tips Grissom and Sara to a new suspect in the crime lab. Also, Folsom and Allie investigate a series of chilling killings at a dilapidated clown-themed hotel.
An abandoned horse covered in blood leads the CSI team to a halfway house for convicted murderers. Also, Grissom and Sara begin to circle their prime suspect in the David Hodges case.
When David Hodges goes missing, the entire CSI team searches for any piece of evidence that can help locate him, clear his name and save the reputation of the entire crime lab.