A drunken Chandler fools around with one of Joey's sisters--but he can't remember which one.
The doctors of County General Hospital in Chicago experience a difficult 24 hours in the series permiere.
A teenage girl is brought to the hospital with severely swollen appendages after a wild night out; as her condition worsens, the patient is unable to distinguish fact from fiction; the doctors attend a medical conference.
Pete, Violet, Sam and Addison adjust to their new lives; Addison second-guesses her desire for a baby; Violet thinks about dating a paramedic.
Jessica's friend Dennis Stanton (Keith Michell) is called to investigate when a purported Mark Twain manuscript leads to murder.