Two outlaws rob a stage, kill the driver and leave the shotgun guard for dead. The guard survives the attack and, with the help of a passerby, manages to make it to Diablo.
A crooked gambler sets his sights on a banker recently arrived from the East.
A Dutch gunsmith shows Annie the revolutionary new rifle he has developed for the army of his adopted country, but word of it spreads and outlaws become interested.
While visiting the port town of Vista, Texas, Doctor Baxter comes across one of histories most fatal plagues.