A crooked gambler sets his sights on a banker recently arrived from the East.
A Dutch gunsmith shows Annie the revolutionary new rifle he has developed for the army of his adopted country, but word of it spreads and outlaws become interested.
Two outlaws rob a stage, kill the driver and leave the shotgun guard for dead. The guard survives the attack and, with the help of a passerby, manages to make it to Diablo.
While visiting the port town of Vista, Texas, Doctor Baxter comes across one of histories most fatal plagues.